U937 cytokine secretion inhibited by HIV-1 gp120 C4-derived peptide constructs.

2004 SEP 2 - (NewsRx.com & NewsRx.net) -- U937 cytokine secretion is inhibited by HIV-1 gp120 C4-derived peptide constructs.

According to a study from the United States, "Lipopolysaccharide (LPS) stimulation of the human promyelomonocytic cell line U937 results in interleukin 6 and interleukin 10 secretion. Modulation of cytokine secretion in response to LPS may be possible through binding of ligands to surface receptors.

"A peptomer, containing multiple repeat units of the CD4-binding C4 region of HIV-1 gp120, and the monomeric C4 peptide each were investigated for their ability to affect LPS-induced IL-6 and IL-10 secretion."

"The peptomer …